Antibody's outside-in signaling shows a route into cancer cells
A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...
Frontiers20 天
Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target
Cadherin family includes lists of transmembrane glycoproteins which mediate calcium ... In conclusion, cadherins play a vital role in tumor angiogenesis mainly through binding to VEGFR or ...
来自MSN17 天
Study Shows How Anticancer Drug is Drawn into Cancer Cells
A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell.
jmg.bmj19 天
Clinical spectrum and pleiotropic nature of CDH1 germline mutations
3 Medical Faculty of the University of Porto, Porto, Portugal ...
Frontiers19 天
RNF20 Is Critical for Snail-Mediated E-Cadherin Repression in Human Breast Cancer
Background: E-cadherin, a hallmark of epithelial-mesenchymal transition (EMT), is often repressed due to Snail-mediated epigenetic modification; however, the exact mechanism remains unclear. There is ...
Scientific Research Publishing10 天
Molecular Mechanisms of the CIRBP Family in Tumors: Current Status and Future Perspectives ()
CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...
eLife2 天
Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers
This study demonstrates the critical role of Afadin on the generation and maintenance of complex cellular layers in the mouse retina. The data are solid, which provides important insights into how ...
Nature20 天
Ubiquitin-binding domains — from structures to functions
Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Specific ubiquitin–UBD interactions are crucial for the regulation of multiple ...