The first is the CoREST complex, which is involved in the regulation of gene expression through epigenetic mechanisms 4. The second is KBTBD4, which is part of a class of protein complexes called ...

为了深入研究这些机制，该研究使用了深度突变扫描技术来描绘KBTBD4突变热点的突变景观，并曝光了隐含的功能获取机制对不同类型突变的偏好，再结合冷冻电子显微镜对KBTBD4癌变体与LSD1–HDAC1–CoREST复合物的结构分析，揭示了癌症突变如何通过改变蛋白质表面 ...