The EMBO Journal12 天
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...
BioWorld1 个月
Discovery of novel LSD1 inhibitors with favorable PK and activity in models of AML
Researchers from Shenyang Pharmaceutical University and affiliated organizations have detailed the discovery and preclinical characterization of novel reversible lysine-specific demethylase 1 (LSD1) ...
BioWorld1 个月
Suzhou Puhe Biopharma divulges new CoREST/HDAC complex inhibitors
Suzhou Puhe Biopharma Co. Ltd. has disclosed histone deacetylase 1 (HDAC1) inhibitors acting as REST Corepressor 1 (RCOR1; CoREST)/histone deacetylase (HDAC) complex inhibitors reported to be useful ...
Frontiers2 年
Lysine specific demethylase 1 is a molecular driver and therapeutic target in sarcoma
In embryonic stem cells, the LSD1-CoREST complex plays important roles suppressing differentiation and promoting ... IMG7289, INCB059872, combination LSD1 and HDAC inhibitors; JBI-802, Corin, and ...
Frontiers2 年
A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms ...
Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological processes. Lysine-specific demethylase 1 (LSD1), a first identified histone ...