Malfunctioning of the enzyme CDK7 is crucial to many cancers, making drugs that target it a high priority. Despite some ...

在细胞生物学研究中，为探究 DNA 复制与有丝分裂的联系，研究人员以细胞周期为主题开展研究。他们发现有丝分裂激酶的逐渐激活可确保 CDK1 依赖性转录，且激活时间影响有丝分裂进程。该研究揭示了细胞有丝分裂准备的调控机制，意义重大。

Cancer drugs that inhibit CDK7 rapidly shut down pathways responsible for cell proliferation within minutes. For organs to ...

Events across the Metroplex have been canceled or delayed as hail and strong winds are expected Saturday morning.

The interplay between aging and cellular senescence reveals insights into chronic inflammation and potential strategies for enhancing healthspan and longevity.

Revolution Medicines, Inc. (Nasdaq: RVMD), a late-stage clinical oncology company developing targeted therapies for patients ...

Press Release Circle Pharma, a clinical-stage biopharmaceutical company focused on developing cell-permeable macrocycle therapeutics, today announced that Chief Executive Officer David Earp, JD, Ph.D.

Zentalis Pharmaceuticals, Inc.’s ZNTL share price has dipped by 12.58%, which has investors questioning if this is right time to buy.

Notably, Cyclin D1 protein plays a crucial role in miR-146b-induced BCa cell proliferation, as confirmed by Western blotting (p < 0.05), with each experiment performed in triplicate. Mechanistic ...

December 31, 2024, with projected cash runway into late 2027 SAN DIEGO, March 26, 2025 (GLOBE NEWSWIRE) -- Zentalis ® Pharmaceuticals, Inc. (Nasdaq: ZNTL), a clinical-stage biopharmaceutical company ...

For decades, cancer researchers and pharmaceutical companies have eyed cyclin dependent kinase (CDK7) with interest due to its role as a "master regulator" of cell proliferation. CDK7 does this in two ...

In this article, García-Vázquez et al. report valuable findings demonstrating that G2 and S phases expressed protein 1 (GTSE1), is a previously unappreciated non-pocket substrate of the cyclin ...