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Emerging data from the basic science laboratory is starting to shed some light on the mechanistic basis of this disease, which may lead to the development of long-term therapies for patients with AF.

On day 12, the melanocytes were harvested and lysed for Western blot analysis to detect the expression of pro-melanogenic factors, including tyrosinase (TYR) and dopachrome tautomerase (DCT) (Figure 5 ...

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2012). Second, melanocytes arise from neural crest cells all along the anterior-posterior axis. The molecular pathways for melanocyte cell fate determination along this axis are poorly understood ...

The neural crest is a dynamic progenitor cell population that arises at the border of neural and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP at the neural plate border are well ...

Important pigment enzymes which cause hypopigmentary phenotypes when defective include tyrosinase (TYR), dopachrome tautomerase (DCT), and tyrosinase related protein-1 (TRP1). Complexion and UV ...