In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

DNA double-strand breaks induce local genome maintenance ... provides insights into the regulation and mechanism of SPO11 activity. The CHAMP1 complex, consisting of CHAMP1, POGZ, and HP1α ...

A study published in Nature Communications and conducted by researchers from the Institute of Physics of the Chinese Academy of Sciences revealed new ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...

When human cells are under ionizing radiation (IR), either in radiation therapy or in adverse environmental conditions, DNA damage occurs, including single-strand breaks (SSBs), base pair damage, and ...

Our cells constantly receive DNA damage from factors such as ultraviolet rays, irradiations, toxins and chemicals. For women, ...

Mitochondrial DNA (mtDNA) is actively removed during spermatogenesis in a conserved process that enforces the uniparental ...

Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, China ...