Dendritic cells (DCs) are professional antigen-presenting cells located in the skin, mucosa and lymphoid tissues. Their main function is to process antigens and present them to T cells to promote ...

1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

However, dendritic cells (DCs), which rely on a specialized endocytic machinery that confers them the unique ability to “cross”-present antigens acquired by internalization, may use distinct MHC I ...

1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 2Department of Surgery, Keio ...

Potential autoimmune diseases therapies that target dendritic cells aim to either inhibit immunogenic dendritic cell functions or support their tolerogenic potential (Figure 2). Most strategies ...

研究表明，胶质母细胞瘤（GBM）类器官是一个强大而准确的工具，可以了解我们用CAR-T细胞疗法治疗脑瘤时到底会发生什么。 孕期机体肠道微生物组 ...

Multiple sclerosis (MS) is considered to be a predominantly T-cell-mediated disease, and emerging evidence indicates that dendritic cells have a critical role in the initiation and progression of ...

They provide convincing evidence for the effectiveness of IL-15/12-conditioned NK cells in this design, which was also critical for the authors being able to conclusively reveal the T cell-dependency ...

This valuable study provides solid in vivo data that transfer of IL-15/IL-12-conditioned syngeneic NK cells after primary tumor resection promotes long-term survival of mice with low metastatic burden ...

The endogenous MHC class I pathway is reserved for peptides ... Figure 1: Molecular mechanisms of licensing dendritic cells for classical cross-priming. Viral infections. Cross-priming is ...

Myhealthchecked Plc Ord 1.5p is listed on the London Stock Exchange trading with ticker code MHC.L. It has a market capitalisation of £9.37m, with approximately 52.04m shares in issue.

Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells ... like PRR and major histocompatibility complex class II (MHC-II), adhesion proteins, and signaling ...