In this manuscript, the authors describe a new AlphaFold2 pipeline called PabFold that can represent a useful tool for identifying linear antibody epitopes (B-cell epitopes ... existing protein ...

When you first enter a new world, you can either spawn near a structure or find one while exploring any of the three dimensions. While finding some can be quite easy, others are extremely hard to ...

Silke Metz and colleagues reported a bsAb prodrug that relies on the proteolytic cleavage of linker peptides to remove steric hindrance within the antibody structure. This bsAb targets HER3 in a ...

In addition to their origin, they fundamentally differ in specificity and utilization. Because immunoglobulins are matched to a specific pathogen, they can be used to diagnose some diseases based on ...

Sjögren’s antibody testing is done using a blood sample. It checks antibody levels, including anti-SS-A (also called anti-Ro) and anti-SS-B (also called anti-La). Anti-SS-A and anti-SS-B are ...

and still retain the functionality of the antibody structure. Figure 1: Schematic diagram for the construction of n-CoDeR, using in vivo-proofread gene segments. In the present investigation we ...

Furthermore, we observed a shift in BCR CDR-H3 properties towards less mature and less specific BCR repertoire in tumor-infiltrating B-cells compared to circulating B-cells, which may indicate less ...

Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby providing protection. But Scripps Research scientists have now discovered that for some HIV ...

Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby providing protection. Scientists at Scripps Research have now made a new discovery for some ...

The company's lead antibody product candidate is Cosibelimab, which is in Phase 1 clinical trial to treat patients with selected recurrent or metastatic cancers; and CK-302, a product candidate in ...

The team believes that the structure was in use until the 8th century BCE, the middle of the period when the Kings of Judah ruled. A scarab seal from the 8th century BCE uncovered during the ...