This patent highlight describes novel substituted 5,6-fused and 6,6-fused bicyclic compounds as 15-prostaglandin dehydrogenase (15-PGDH) modulators. It provides a detailed account of their synthesis, ...

These compounds, characterized by a bicyclic structure that includes a benzene ring fused to a thiazole ring, exhibit a wide range of biological activities. Their versatility makes them valuable ...

In his work "The Four Elements of Architecture," Semper argued that architecture didn't begin with permanent structures, but with textiles. He described how early humans first gathered around the ...

Almost everything else is on his block gone. As many as 12,000 homes, businesses and other structures may have been destroyed in the wildfires raging in Los Angeles County, rendering entire ...

Farm structures are also known as farm buildings. They are built on a farm, especially on big farms, used for farming operations. A farmhouse is a structure that serves mainly as a home for families, ...

The team believes that the structure was in use until the 8th century BCE, the middle of the period when the Kings of Judah ruled. A scarab seal from the 8th century BCE uncovered during the ...

Earth's inner core may actually have two distinct layers. (alexlmx/Canva Pro) "We found evidence that may indicate a change in the structure of iron, which suggests perhaps two separate cooling events ...

Bicycle Therapeutics has developed a new class of therapeutics based on its proprietary bicyclic peptide (Bicycle) product platform, and will gain funding for phase 1 and phase 1b clinical trial ...