The nanny model of IDPs is distinct from the chaperone model of globular proteins. In the case of globular proteins, the newly synthesized polypeptide chains fold first to a compact molten globule ...

Fibrous proteins have their long, spiral chains folded to form long, thin shapes. They are strong and are generally insoluble in water. Globular proteins are molecules involved in the regulation ...

Mnl1 demannosylates misfolded, globular proteins and Pdi1 then reduces the disulfides to generate unfolded proteins competent for ERAD. This study expands the molecular grammar of FUS, identifying ...