Monoclonal antibodies (mAbs) are nature's biological ... are treated with other immunosuppressants and are less prone to HAMA reactions. If mAbs were to become a class of successful therapeutics ...

Too often, this practice elicited harmful human anti–mouse antibody responses, which prompted efforts to reengineer rodent mAbs, somewhat laboriously, to look more like human antibodies and thus ...

The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in ...

the clinical application of mouse monoclonal antibodies is limited by the human anti-mouse antibody (HAMA) response. Humanization of mouse monoclonal antibodies or alpaca nanobody by genetic ...