在复制阶段，7 种蛋白质（IL23R、ERAP2、IFNLR1、KIR2DL3、NEO1、CLSTN3 和 POLR2F）在 FinnGen 数据集中成功得到验证（ ） 。其中，遗传预测的 NEO1 水平较低与 PsA 风险增加相关，而其他 6 种蛋白质（IL23R、ERAP2、IFNLR1、KIR2DL3、CLSTN3 和 POLR2F）水平升高与 PsA 风险增加相关。

The researchers focused specifically on the IL23R gene, which plays a key role in immune regulation. "The exact causes of chronic inflammatory bowel diseases remain unknown. However, previous ...

Figure 2 Studies of concordance for AS in UK twins recruited through the National Ankylosing Spondylitis Society. The clear difference on concordance rates between MZ twins and DZ twins is highly ...