The completed vesicle fuses with the vacuole, the yeast analogue of the mammalian lysosome. The larger size of the vacuole allows the release of the inner single-membrane compartment of the Cvt ...

Soluble proteins are carried in the lumens of vesicles. Any proteins that are destined for a lysosome are delivered to the lysosome interior when the vesicle that carries them fuses with the ...

In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles," published in Proceedings of the National Academy of Sciences ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

Homotypic fusion between late endosomes. (A) Time-lapse imaging of endocytic vesicles in VE cells. (B) By labeling of VE ...

This information is of particular importance to patients with Danon’s disease, who have mutations in a lysosomal protein that causes cardiomyopathy. We discovered that fibroblasts and cardiac myocytes ...