Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...

RNA-seq 分析发现，ELOVL6 抑制导致 202 个基因差异表达，GSEA 分析表明，未处理细胞在 “myc targets” 和 “cell cycle” 通路富集度更高，而脂质代谢相关通路在未处理细胞中也更富集，说明 ELOVL6 抑制使这些通路下调。细胞信号磷酸激酶阵列实验发现，细胞增殖相关 ...

Known as c-Myc, the protein is encoded by one of the first cellular oncogenes discovered in humans and has since been found to be dysregulated in more than 50 percent of all human cancers. The peptide ...

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...