This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse ...

In this application note, explore how scientists can couple a serum-free medium with a xeno-free serum replacement to effectively culture functional monocyte-derived dendritic cells and macrophages.

Selectively inactivating a molecular switch that turns on the gene Nr4a1 in monocytes but not macrophages leads to the loss of patrolling monocytes, which play an important role in suppressing ...

Our expertise includes the isolation and culture of primary human and rodent cells (lymphocytes, monocyte/macrophages, and other immune cells; fibroblast-like synoviocytes; myoblasts), functional ...

Macrophages eat other cells and are able to pull apart their proteins in order to ... Raveney, B. J. E., and Munder, M. (2009) Monocyte dependent regulation of autoimmune inflammation.

This diagram illustrates the role of macrophage ATF6 in orthodontic tooth movement. When corticotomy is applied, monocytes are recruited to the bone, where they differentiate into pro-inflammatory ...

The lab's discovery was published in the paper, "Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma," in the journal Immunity.

More information: Alexander Simonis et al, Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages, Molecular Systems Biology (2025). DOI: 10.1038/s44320-025 ...