Furthermore, myosin heavy chain II (MyHC II), skeletal muscle-specific transcription factor (MyoD), muscle RING-finger protein-1 (MuRF1), and FNDC5 levels were evaluated in the quadriceps muscle. The ...

(1) The authors mainly rely on coarse and less-established readouts such as myotube length and spherical Myh-positive cells. More comprehensive and standard analyses, such as co-staining for Pax7, ...

Finally, we provide evidence to suggest that lineage-determining TFs recruit and require MLL4 to establish cell-type-specific enhancers. RNA-Seq analysis of myogenesis of MyoD-expressing brown ...