这项研究揭示了赖氨酸甲基转移酶SMYD3在调节抗先天免疫中的作用，并为影响其激活的IRF3的调节机制提供了新的见解。 狂犬病（RABV）是丽莎属的 ...

这项研究揭示了赖氨酸甲基转移酶SMYD3在调节抗病毒先天免疫中的作用，并为影响其激活的IRF3的调节机制提供了新的见解。 狂犬病病毒（RABV ...

At the core of this pathway is cGAS-dependent production of the intra- and extra-cellular messenger cGAMP, which activates STING and leads to IRF3-dependent expression of cytokines and interferons.

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.

More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...

SCs 通常处于静止状态，表达转录因子配对盒 7（Pax7）。当肌肉受伤时，静止的 SCs 会被激活并分化，这一过程受肌源性决定因子 1（MyoD）调控。众多生长因子和细胞因子参与调节骨骼肌的生长和再生，其中肌肉生长抑制素（Mstn，属于 TGF - β 超家族成员，也被 ...

TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls ...

In this study, we reported that IRF3 can negatively regulate TRIF-mediated NF-κB signaling pathway. Overexpression of IRF3 can inhibit TRIF-mediated NF-κB signaling pathway. However, knockdown of IRF3 ...

Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA-dependent protein ...