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Rho 激酶抑制剂法舒地尔对大鼠海马突触可塑性的调控作用:解锁神经 ...
为探究 Rho 激酶(ROCK)抑制对低频刺激(LFS)引发的长时程增强(LTP)抑制的影响,研究人员以成年雄性大鼠为对象开展实验。结果发现法舒地尔可阻碍齿状回神经元抑制突触 LTP,且伴有 GSK- 3 β 和 tau 蛋白磷酸化水平下降,这对研究神经可塑性及相关疾病治疗有重要意义。
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