为探究 Rho 激酶（ROCK）抑制对低频刺激（LFS）引发的长时程增强（LTP）抑制的影响，研究人员以成年雄性大鼠为对象开展实验。结果发现法舒地尔可阻碍齿状回神经元抑制突触 LTP，且伴有 GSK- 3 β 和 tau 蛋白磷酸化水平下降，这对研究神经可塑性及相关疾病治疗有重要意义。

追问快读：人类关于记忆奥秘的探索，竟始于对兔子的脑细胞实验。半个世纪前，当科学家用电信号刺激兔脑海马体时，他们怎么也想不到，竟误打误撞摸到了打开人类记忆殿堂的“钥匙”。这种被称为“长时程增强”（LTP）的机制，就像大脑在反复练习后“记住”了某种信号， ...

Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

50多年前，年轻的洛莫正在挪威奥斯陆研究大脑中的海马体。这一区域是哺乳动物储存记忆的关键。他想知道，使用重复的电脉冲模仿神经信号是否能让神经元对后续刺激更加敏感。为了找到答案，他向一只兔子的神经元发送定时电流脉冲。令他惊讶的是，细胞的反应增加了，有时甚至持续了几分钟。这一特异现象虽然引起了洛莫的关注，但遗憾的是，他并没有坚持研究下去。

让我们从一个简单的实验说起。50多年前，挪威奥斯陆的一位年轻科学家特耶•洛莫 (Terje Lømo)正在研究大脑中的海马体，这是哺乳动物储存记忆的关键区域。他想知道，使用重复的电脉冲模仿神经信号是否能让神经元对后续刺激更加敏感。于是，他向一只兔子的神经元发送定时电流脉冲。令他惊讶的是，细胞的反应增加了，有时甚至持续了几分钟。

Trump's third term: US President Donald Trump stirred a new debate by dropping a hint that he is considering ways to breach a constitutional barrier against continuing to lead the country after ...

Ashlee is an insurance editor, journalist and business professional with an MBA and more than 17 years of hands-on experience in both business and personal finance. She is passionate about ...

Putin got rid of term limits in the Kremlin and Trump is openly toying with staying past eight years in the White House, telling NBC News that he’s “not joking” about seeking a third term in ...

President Donald Trump may be publicly musing about serving a third term in the White House but the 22nd Amendment to the US Constitution makes such a scenario highly unlikely. Trump, 78, said ...

Media personality Stephen A. Smith blasted Republicans for entertaining the possibility of President Trump running for a third term in office. “Wait a minute, you’re a Republican voter out there.

Weeks into his second term, President Donald Trump has stated he is "not joking" about the possibility of serving a third term in office despite the U.S. Constitution's two-term limit."I have had ...