The most frequent ANA patterns in PBC sera are the 'speckled' (Figure 1), the multiple nuclear dots (MND; Figure 2), the rim-like/membranous (RL/M; Figure 3) and the anticentromere (ACA ...

The MND ANA pattern is immunomorphologically characterized by the staining of 3–20 dots of variable size distributed throughout the cell nucleus, but sparing the nucleoli and the mitoses (Figure 2).