eLife21 天
p53 engagement is a hallmark of an unfolded protein response in the nucleus of mammalian cells
Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent cell cycle delay. These studies highlight the distinct effects ...
Cancer Research24 天
KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than ...
Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts. *Corresponding Author: Yogesh K. Chutake, Kymera Therapeutics, Inc., 500 North Beacon ...