Juvenile Paget disease (JPD) is a very rare disease, mainly caused by biallelic inactivating mutations in the TNFRSF11B gene that encodes osteoprotegerin. Owing to its rarity, the treatment of JPD is ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Intensive bisphosphonate treatment does not confer a clinical advantage over treatment of symptoms alone in patients with Paget disease of bone. Findings from a UK study reveal that maintenance of ...

Alendronate sodium is a bisphosphonate used to treat Paget disease of bone (PDB ... from baseline by 73% and 72% in the tablet and OBS treatment groups, respectively. The incidence of non ...

Diagnosis is confirmed by removing a small piece of tissue, known as a biopsy, and examining it under a microscope. The treatment of Paget's disease is surgery to remove the affected area of skin.

treatments and research advances? Dear Reader: The full name of the condition you have been diagnosed with is Paget’s disease of bone. Also known as osteitis deformans, it is a chronic bone ...

Considering taking supplements to treat paget disease? Below is a list of common natural remedies used to treat or reduce the symptoms of paget disease. Follow the links to read common uses ...