Amyloid was then subclassified by immunohistochemistry. LCDD was diagnosed if renal biopsy showed non– Congophilic, light chain–restricted deposits that were granular by electron microscopy.

depending on factors such as genotype and disease stage. 2-4 The pathophysiology of ATTR-CM involves amyloid deposits accumulating in the myocardium, leading to left ventricular hypertrophy (LVH) and ...

Amyloidosis is a disease complex characterized by the deposition of protein fibrils in various organs ... Cardiac involvement has been predominantly noted in amyloid light chain (AL) amyloidosis (also ...

Previously known as primary amyloidosis, systemic amyloid light chain (AL) amyloidosis is the ... This type is an autosomal dominant disease in which the genetically inherited variant form of ...

has granted Fast Track Designation to [18F]florbetaben for the diagnosis of cardiac amyloid light-chain (AL) and amyloid transthyretin-related (ATTR) amyloidosis. Fast Track is an FDA process designed ...

Studies on amyloidosis involving the oral cavity included studies on light chain amyloidosis, transthyretin amyloidosis (ATTR), amyloid ... and early diagnosis after 2015. ATTR is a disease ...

Isatuximab is under clinical development by Sanofi and currently in Phase II for Primary Systemic Amyloidosis. According to GlobalData, Phase II drugs for Primary Systemic Amyloidosis does not have ...

Renal biopsies from the two patients were examined by routine light microscope (HE, PAS, Masson trichrome, Silver methenamine and Congo red), Immunofluorescence (detection for IgG, IgA, IgM, C3, C1q, ...

This cross-sectional study aimed to evaluate the ability of plasma biomarkers, including amyloid β (Aβ), total tau (t-tau), and neurofilament light chain (NfL), to detect ... illiteracy > 17, primary ...