In this study, non-directiveness applies to the approach of the counselling team towards family members besides the proband. When a BRCA1/2 gene mutation is found in a family, the possibility of ...

Genetics significantly impact cancer risk, particularly in inherited mutations like BRCA1/BRCA2, which increase susceptibility to breast and ovarian cancer. Expert advice suggests that ...

It is still controversial whether IM itself is a precancerous or paracancerous lesion. With crypt isolation, IM cells had a unique DNA methylation profile, especially extensive hypermethylation in ...

Background Hereditary causes of ovarian cancer include Lynch syndrome, which is due to inherited pathogenic variants affecting one of the four mismatch repair genes involved in DNA repair ... where ...

Having a parent or sibling with diabetes does mean you are more likely to develop it yourself. But diabetes isn't just caused by genetics. Having a relative with the disease doesn't guarantee you will ...

Get Instant Summarized Text (Gist) A new approach, PERISCOPE, integrates Cell Painting and Optical Pooled Screening to enable genome-scale CRISPR screens, linking cell morphology to gene function ...

With the exception of pediatric cancers and some adult cancer types that are caused by inherited genetic mutations (e.g., BRCA1 mutations in breast cancer), the ... the main alteration affecting these ...

The company, which secured $200 million from investors in a private funding deal last week, learned Tuesday of a serious side effect experienced by one participant on a high dose of its Rett therapy.

Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF. Nucleic Acids Research , 2025; 53 (1) DOI: 10.1093/nar/gkae1281 Cite This Page : ...

Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don't produce ...

These changes occur rapidly and are significant in magnitude—several hundred genes can change within 10 to 15 minutes. Moreover, these changes appear to persist for at least an hour following ...

Penske Entertainment has taken over the promotions of the NTT IndyCar Series season finale at Nashville Speedway. The change comes after Scott Borchetta’s Big Machine Music City GP promotions team put ...