Proteolysis is the enzymatic process by which proteins are degraded into their component polypeptide or amino acid parts. This generally occurs through protease-mediated hydrolysis of peptide ...

The range of proteases present in LROs is cell-type specific. Endolysosomal proteolysis can involve relatively non-specific degradation, as in the formation of antigenic peptides by antigen ...

ARV-102 is Arvinas’ investigational PROteolysis TArgeting Chimera (PROTAC) degrader targeting leucine-rich repeat kinase 2 (LRRK2), a multifunctional protein that has been implicated in Parkinson’s ...

In a recent study published in the journal Nature, researchers from the United States of America developed the synthetic intramembrane proteolysis receptor (SNIPR) architecture to activate ...

– Vepdegestrant is the first PROTAC degrader to demonstrate clinical benefit in a Phase 3 trial – ...

One of his current research programs focuses is the discovery of novel proteolysis targeting chimera’s (PROTACs), a molecule that can utilize our normal cellular machinery to remove unwanted, ...