Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...

hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。

Researchers have shown, for the first time, how the genetic material of the Nipah virus replicates in infected cells. The virus can cause fatal encephalitis in humans.

通过这种方式，流感病毒利用感染细胞的m 6 a修饰系统给自身基因组rna添加m 6 a修饰，直接促进病毒rna与病毒聚合酶蛋白的结合，进而促进病毒聚合酶 ...

Primrose Bio, Inc. ("Primrose"), a company developing proprietary therapeutic manufacturing technologies, announces the ...

For the first time, researchers have visualized the three-dimensional structure of the Nipah virus's RNA polymerase—the enzyme responsible for copying the virus's genetic material—at molecular ...

The University of Hong Kong has patented RNA polymerase β subunit/RNA polymerase sigma factor RpoD (bacterial) interaction inhibitors reported to be useful for the treatment of gram-positive bacterial ...

Primrose Bio announced a new product to improve the manufacturing on long-template mRNA vaccines. 1 The Prima RNApols ExTend ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

To implement the blueprint it contains, RNA polymerase is used. The enzyme reads the information stored in the template and makes the corresponding RNA component. Algorithms specifically developed ...

Vancomycin 265/309 (85.8%) 76/265 (25.3%) 198/309 (64.1%) † Clinical cure is resolution of diarrhea following the recommended dose of drug (fidaxomicin: 200 mg twice a day; vancomycin: 125 mg ...