Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in ...

A Metro Railway engineer explained, "Green Line of Metro Railway, Kolkata, is the first corridor where CBTC signalling system has been commissioned for safe and automatic train operations." ...

Figure 1: a, Sequence alignment of SAM domains from the Eph family of receptor tyrosine kinases and selected ... other protein interaction modules with signaling functions such as SH3, SH2 ...

Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, Otsu, Shiga 520-0811, Japan Key Laboratory of Industrial Ecology and Environmental Engineering ...

Peggy and Charles Stephenson Cancer Center and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States Peggy and Charles Stephenson Cancer ...

The study highlights adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive thermogenesis ... (F and H) Western-blot analysis for level of p-CREB and CREB ...

This cover highlights the article A regulatory module mediating temperature control of cell-cell communication facilitates tree bud dormancy release by Shashank K. Pandey, Jay Prakash Maurya, ...

FIGURE 1. Different structural types of small-molecule MET kinase inhibitors. We focused on the design of new antiproliferative agents with potential interactions with MET active site as type II ...

Interestingly, these events include mutation of well-described oncogenic pathways including cell-/DNA-damage repair mechanisms (TP53, PPM1D, ATM, ATRX) and receptor tyrosine kinase signaling pathways ...

What is the essential forward-grade signaling mechanism used by the receptors that cause vascular mitochondrial fragmentation ... smooth muscle 22 α; and Tie2, tyrosine kinase with immunoglobulin like ...