Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified ... Constitutive ALK signalling induces cell transformation in vitro and in vivo by controlling key cellular ...

It is closely associated with tumorigenesis and drug resistance, making it a potential target for oncology drug development. To date, no ROR1-targeting drugs have been marketed. BR111 utilizes ...

Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of ...

signaling array. Specific goals include elucidation of the mechanisms by which attractant and adaptation signals are transmitted through the transmembrane receptors to the kinase, and how these ...

TIE1, a receptor tyrosine kinase, was found to be upregulated by ... In conclusion, this work has identified a novel signaling pathway involving ING5, TIE1, and PDK1 Y163 phosphorylation that ...