Neurological motor disorders (NMDs) such as Parkinson's disease and Huntington's disease are characterized by the accumulation and aggregation of misfolded proteins that trigger cell death of specific ...

In particular, most members of the NR2 family are among the least studied proteins of the class, and apart from the retinoid X receptors (RXR), validated NR2 ligands are very rare. Here, we gathered ...

Department of Pharmacy, “Drug Discovery Laboratory”, University of Naples Federico II, via Domenico Montesano 49, I-80131 Naples, Italy ...

通过构建基因工程小鼠模型，研究者观察到癌细胞在LGR5+干细胞态与OnF状态之间形成了连续的"表型谱"（phenotypic spectrum）。 在与结直肠癌（colorectal ...

研究显示，APC失活会引发连锁反应： WNT信号通路失控：正常情况下的"刹车"失效，导致干细胞过度增殖 RXR受体失调：调控细胞分化的"守门人"失职 ...

The newly issued senior and mezzanine loans paid off the development’s $102.5 million construction loan that dates to 2022 from Related Fund Management, an affiliate of New York-based Related ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...

RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in ...

Some work as activators, turning genes on, whilst others work as repressors, turning genes off. For example, the transcription factor PPAR alpha is a well-known activator that helps to regulate fat ...

In recent years, our understanding of how environmental signals are integrated into macrophage phenotype has greatly advanced. The classic roles of NOTCH, PI3K/AKT, MYC, PPAR, and interferon ...