Srs2 sumoylation is additionally reliant on Mec1 and peaks after Mec1 activity reaches ... such as at those formed at R-loops. The main functions of RPA at these sites can be ssDNA protection and ...

Results from three biological isolates per genotype are graphed. (E) Mec1 is required for Srs2 sumoylation. Experiments were performed and data are presented as in panel A. Figure 6. Mec1 and RPA ...

Plants mobilize the endomembrane system for restoring homeostasis when stimulated by stresses. Though the function of ufmylation in ER stress and autophagy has been described in mammals, their ...

Giving gene therapy to newborn mice with Batten disease prevented the loss of many nerve cells in the bowel and prevented related problems with bowel function. The mice treated by gene therapy ...