Peripheral T-cell ... protein (GFP) Lentiviral vector, using Lipofectamine 2000 (Life Technologies, Carlsbad, CA, USA) per the manufacturer’s protocol. Prior to lentiviral transduction ...

Here we report a case of a T-cell lymphoma harboring a lentiviral integration in ... after infusion may have cooperated with CAR activity, CAR vector integration in TP53, or both to contribute ...

Viral gene delivery is a ubiquitous laboratory technique with a myraid of uses. Understanding the basics of gene delivery workflows, from vector selection and cloning to transduction, is a fundamental ...

Within a large group of more than 700 patients treated with CAR T cell therapy ... Jadlowsky et al, Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies, Nature ...

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To create one of the most advanced immunotherapies in cancer, CAR-T cell therapies, scientists engineer immune T cells to carry a synthetic protein on their surfaces. This protein, called the ...