生物通5 天
AMPK-TFEB/TFE3-DNMT3A/DOT1L轴与JNK-AP-1通路在颗粒诱导的炎症和溶酶体反应 ...
为解决颗粒暴露引发炎症疾病的机制问题，研究人员开展研究，揭示了AMPK-TFEB/TFE3-DNMT3A/DOT1L轴调控溶酶体酸化基因，JNK-AP-1 ...
Baylor College of Medicine2 年
TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy
Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...