The short arm was soon identified, by Margaret Dayhoff, as ubiquitin, a 76-residue protein of unknown function that was described (as a free protein) by Gideon Goldstein and colleagues in 1975 (ref.

Intrinsically disordered proteins (IDPs) are subject to ubiquitin-independent degradation, a default and passive process. We describe here a model wherein a group of 'nanny' proteins function to ...

Ubiquitin ligases regulate many processes in ... Dimerization is, therefore, an important regulatory mechanism." "If HACE1 no longer functions correctly in the cell or is missing altogether ...

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through adenylation ... These studies were followed by an in vivo screen in yeast that uncovered at least three critical E2 ...