Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Continue to advance preclinical and research pipeline, including key programs selectively combined with Alector Brain Carrier, enhancing the company's commitment to developing genetically-validated th ...

Continue to advance preclinical and research pipeline, including key programs selectively combined with Alector Brain Carrier, enhancing the ...

Scientists have uncovered how developing neurons migrate from the germinal zone, a process critical for proper brain circuit formation.

Ubiquitin ligases facilitate the recycling ... wherein cell–cell contact and Netrin-1 sensing inputs must function for the correct output to be seen. "With other techniques such as single ...

Micronutrients (those needed in smaller amounts) include vitamins and minerals. Every nutrient has unique functions. Deficiencies in a specific vitamin or mineral, for example, increase the risk of ...

This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as ...

Some cancer drugs cause severe side effects because they are not working accurately enough. A team at the University of Würzburg led by biochemist Caroline Kisker has now discovered why.

Our data also provide clues to biological function for hundreds of previously uncharacterized human genes. We set out to identify cell-cycle–regulated transcripts in human cells on a genome-wide ...

Ubiquitin Binding Protein 2-like (UBAP2L, also known as NICE-4) is a ubiquitin- and RNA-binding protein, highly conserved in metazoans. Despite its abundance, its functions have only recently started ...

although other studies have shown that the loss of Ube3A expression during development leads to mental retardation (Angelman’s syndrome), and later disruptions in ubiquitin-mediated proteasomal ...