One specific system under investigation is the ubiquitin-proteasome system (UPS). This system plays a central role in most cellular processes. New data suggest that UPS plays a role beyond its known ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Disorders of surfactant protein biology cause ...

This finding suggests that CHIP plays a central role in cGMP/cAMP signalling crosstalk. CHIP mutation prompts the upregulation of cAMP, increasing PKAc and further competitively inhibiting the ...

In light of these considerations, this review comprehensively synthesizes recent research findings concerning the TLR4/NF-κB signaling pathway, including the translocation of TLR4 activation to ...

In this study, we demonstrate the feasibility of generating virtual stains for hematoxylin and eosin (H&E) and a multiplex immunofluorescence (mIF) immuno-oncology panel (DAPI, PanCK, PD-L1, CD3, and ...

(G) Representative immunofluorescence images of Ub staining in cells treated with MG132 or transfected with various sPINK1 constructs, highlighting differences in ubiquitin localization and ...

RR indicates relative risk; SBP, systolic BP; IDACO, International Database on Ambulatory BP in Relation to Cardiovascular Outcome; sleep-through surge, 2-h morning SBP minus 1-hour lowest nighttime ...

Ubiquitination involves the covalent attachment of the protein ubiquitin to substrates. It can be reversed by the action of deubiquitinating enzymes (DUBs), thereby providing an important layer of ...

Fluorescence was excited and detected as follows: GFP 488 nm/505–525 nm, mCherry 568 nm/580–610 nm, chlorophyll fluorescence 514 nm/650–750 nm. Immunofluorescence was performed on roots apex from 8 ...