Pain marks the second therapeutic area for Cullgen’s lead protein degrader CG001419SAN DIEGO, Jan. 22, 2025 (GLOBE NEWSWIRE) ...

Ubiquitin itself can also be modified, resulting in polyubiquitin chains that direct the target to the 26S proteasome for destruction. The APC reaction is processive, such that multiple ubiquitins ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

(I) Western blot analysis of ubiquitin in the insoluble fraction of HEK293 cells post 2-hour OGD and subsequent ... and pK48-polyUb-GFP (H), detailing the dynamic interactions at the proteasome ...

Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ...

Degradation of proteins mediated by the ubiquitin–proteasome system regulates key cellular processes, including cell cycle progression, inflammation, and neurodegenerative diseases, and the proteasome ...

A and B symbolize peptides or proteins. A ubiquitin substrate with a C-terminal Connectase recognition sequence followed by a Streptavidin-tag (Ub-Strep) is fused to peptides consisting of N-terminal ...

Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Between 2009 and 2013, I performed my PhD in Medical Microbiology under the supervision of Prof. Jan Maarten van Dijl and Prof. Grietje Molema studying how Streptococcus pneumoniae interact with ...

The COG analysis revealed also nucleolar enrichment of proteins linked to protein dynamics. More precisely, in the COG O category, 27% of the proteins correspond to 26S proteasome subunits while the ...