AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand.

AMPK is a highly conserved sensor of intracellular adenosine nucleotide levels that is activated when even modest decreases in ATP production result in relative increases in AMP or ADP. In response, AMPK promotes catabolic pathways to generate …

1 天前 · AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis that also plays a role in preserving mitochondrial function and integrity. ... In vivo, AICAR is converted to the inosine pathway intermediate ZMP that acts as an AMP analog. ... Images of the gel were recorded using a high-quality imager (Epson Perfection ...

AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that ...

2024年4月18日 · Recent data suggests that AMPK plays a function in redox equilibrium and oxidative stress control during diabetes-related disorders by regulating several pathways. AICAR-activated AMPK has been demonstrated to boost the promoter function of 8-Oxoguanine glycosylase 1 (OGG1), a DNA repairing enzyme, via upregulating nuclear factor erythroid 2 ...

At the core of the pathway is AMPK, which is activated in response to energy depletion. Cellular energy states are constantly monitored by AMPK, which becomes activated when the ATP/AMP/ADP ratio shifts due to stressors such as glucose deprivation, hypoxia, or physical exercise . Once activated, AMPK initiates broad metabolic changes to ...

2024年11月11日 · We found that AMPK directly inhibits NIX-dependent mitophagy by triggering 14-3-3-mediated sequestration of ULK1, via ULK1 phosphorylation at two sites: Ser556 and an additional identified site, Ser694. By contrast, AMPK activation increases Parkin phosphorylation and enhances the rate of depolarization-induced mitophagy, independently of ULK1.

2022年10月31日 · Recent advances revealed several non-canonical pathways for AMPK activation, including roles of calcium, nutrients and metabolites, as well as DNA and lysosome damage, providing novel...

2023年11月7日 · Confocal microscopic images were performed to indicate the mitochondrial dynamics, LC3 level, and AMPK translocation after UVA irradiation. We confirmed mitochondrial ROS production and DNA damage are two major features caused by UVA.

2025年1月30日 · AMP-activated protein kinase (AMPK) is a central mediator of cellular metabolism and is activated in direct response to low ATP levels. Activated AMPK inhibits anabolic pathways and promotes catabolic activities that generate ATP through the phosphorylation of multiple target substrates. AMPK is a therapeutic target for activation in several chronic metabolic diseases, and there is increasing ...