Cloprostenol has been used to terminate pregnancy in any animal that forms a corpus luteum. Most reports on successful termination of pregnancy have been performed on cattle, horses, and dogs. In dogs, cloprostenol has been administered in combination with other drugs (e.g., cabergoline [Dostinex] and bromocriptine [Parlodel]) to terminate ...

2012年1月1日 · D-cloprostenol is approximately 10-fold more potent than DL-cloprostenol [12], so when D-cloprostenol is used a lower dosage is effective. Compared to Dinoprost, cloprostenol has a greater affinity for PGF2α receptors [13] and a longer half life in the circulation, 3 h vs a few minutes [9] , because in cloprostenol a benzyl chloride ring is ...

Comparing the in vitro binding affinity and functional activity of PGF 2α, cloprostenol, and the carboxylic acid of travoprost, it is clear that travoprost acid is much more selective (Tables 5 and 6). 19 These results suggest that, although activity at the FP receptor is adequate to afford ocular efficacy, selectivity for the FP receptor ...

Currently PGF 2α, cloprostenol, and other analogues are the most satisfactory treatment. Most pyometra cases can be successfully evacuated by one or more injections of prostaglandin drugs. Treatments may be repeated at 14-day intervals. PGF 2α (35 mg) or 500 mg of cloprostenol has given excellent results. This treatment also works well for ...

2011年6月1日 · Cloprostenol sodium tended to improve P/AI compared with dinoprost tromethamine when used within Ovsynch preceded by a presynchronization program. More importantly, cows with greater serum concentrations of P 4 at time of PGF 2α of Ovsynch had a greater chance for luteolysis and pregnancy.

2023年9月1日 · Cloprostenol causes the contraction of uterine and bronchial muscles and also causes vasoconstriction of blood vessels (Cavanagh). Cloprostenol is readily absorbed through the skin. Exposure to cloprostenol is a great risk to human health for pregnant women, childbearing age and asthmatics.

2023年6月1日 · To study the effect of different doses of d-cloprostenol treatment on luteolysis and estrous cycle, the jennies were treated with 0.2 mg (n = 30), 0.4 mg (n = 30), or 0.6 mg (n = 30) cloprostenol by intramuscular injection in the neck at 9 am on the fifth day following ovulation. Daily B-mode ultrasound examinations were performed at 9 am every ...

2012年9月1日 · Cloprostenol sodium is a potent synthetic analogue of PGF 2α that is resistant to endogenous metabolism because of an oxyaryl function [1] and thus has a long half-life (T ½ ∼ 3 h) [2]. Comparatively, dinoprost has a short half-life (T ½ ∼ 8 min) [3] and is rapidly metabolized similar to endogenous PGF 2α metabolism [1], [4].

2008年4月14日 · Repeated application of (+)-cloprostenol (sodium salt) affects progesterone concentrations that indicate function of corpus luteum in cows and influences milk production, parity and endometritis [1]. The positive impacts of cloprostenol on the induction of luteolysis but also its clinical side effects were observed in mares [6]. Cows with ...

2024年3月6日 · In cloprostenol-bound FP and TP structures, the binding poses of cloprostenol are very similar, with only the differences in the rotation of the chlorophenoxy ring by ∼30°(Figures 4 B and S6 B). Similar to the PGF 2α -FP binding pocket, cloprostenol bound within the ligand pocket of both receptors through 3 subpockets.