2014年10月17日 · Mannose chemistry, metabolism, and metabolomics in cells, tissues and mammals can help explain these multiple systemic effects. Mannose has good, bad or ugly …

2025年1月13日 · Restoring mannose metabolism through pharmacologic D-mannose exposure enhanced the generation of stem-like T cells via metabolic, epigenetic, and O-GlcNAcylation …

2014年10月17日 · Mannose chemistry, metabolism, and metabolomics in cells, tissues and mammals can help explain these multiple systemic effects. Mannose has good, bad or ugly …

2025年1月17日 · Mechanistically, mannose metabolism enhances T cell stemness through both metabolic reprogramming and epigenetic modifications. Mannose is taken up by the cell via …

Mannose interferes with glucose metabolism in tumor cells with low expression of the MPI gene. Mannose and glucose are transported into cells by the same transporter (GLUT), and …

2024年12月5日 · Enhancing mannose metabolism in T cells through D-mannose supplementation boosts anti-tumor activity, limits exhaustion differentiation, and maintains T cell stemness. …

Mannose is a glucose-associated serum metabolite mainly released by the liver. Recent studies have shown several unexpected pleiotropic effects of mannose including increased regulatory …

2024年3月8日 · Once inside the cell, mannose is phosphorylated by hexokinase to produce mannose-6-phosphate (M6P), which can follow two primary metabolic pathways. A small …

In this paper, we review the research on the metabolic regulation of mannose in regulating immune cell function and immune-related diseases to provide ideas for understanding the …

Mannose in N-glycans is derived from glucose through phosphomannose isomerase (MPI, Fru-6-P ↔ Man-6-P) whose deficiency causes a congenital disorder of glycosylation (CDG)-Ib (MPI …