The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This region allows antibodies to activate the immune system, for example, through binding to …

Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity.

Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions.

To optimize the anti-tumor activity of agonist antibodies’ binding to immunostimulatory TNF receptors, the Fc region of the IgG antibody was engineered to bind more strongly to the FcγRIIB receptor.

The human FcRs belong to the Ig superfamily and are type I transmembrane glycoproteins, which bind to the Fc tail of antibodies. They comprise receptors for all five antibody classes: FcµR (IgM), FcγR (IgG), FcαR (IgA), FcδR (IgD), and FcεR (IgE) [2,8,9].

In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs). In recent years, significant progress has been made in...

2011年2月1日 · Fc receptors (FcRs) are a group of glycoproteins belonging to the immunoglobulin superfamily and are organized into classes, such as FcαR, FcγR and FcεR; FcγRs are expressed mostly on...

2019年11月18日 · In this report, we review Fc engineering efforts to improve therapeutic potency, and propose future antibody engineering directions that can fulfill unmet medical needs.

While one part of the antibody, the antigen binding fragment (Fab), recognizes the antigen, the other part of the antibody, known as the crystallizable fragment (Fc), interacts with other elements of the immune system, such as phagocytes or components of the complement pathway, to promote removal of the antigen.

At Absolute Antibody, we’ve developed Fc Silent™ antibodies for research and assay development use, which have a genetically engineered Fc domain with key point mutations that abrogate binding of Fc receptors and abolish antibody …