In research, 5-azacitidine is commonly used for promoting cardiomyocyte differentiation of adult stem cells. However, it has been suggested that this drug has a compromised efficacy as a …

2016年8月27日 · 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to …

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside present in DNA and RNA. It induces antineoplastic activity by inhibiting DNA methyltransferase at low doses and …

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside present in DNA and RNA. 1,2 It induces antineoplastic activity by inhibiting DNA methyltransferase at low doses …

2018年4月27日 · The cytidine analogs 5-azacytidine (5-AZA, azacytidine) and its deoxy derivative 5-aza-2′-deoxycytidine (5-AZA-dC, decitabine) have shown efficacy for the treatment of …

This substance was considered by a previous Working Group, in October 1980, under the title 5-azacytidine (IARC, 1981). Since that time, new data have become available, and these have …

2002年8月5日 · The finding that 5-azacytidine was incorporated into DNA and that, when present in DNA, it inhibited DNA methylation, led to widespread use of 5-azacytidine and...

5-Azacytidine is a compound that is similar to cytidine and is known for its cancerostatic, bacteriostatic, and mutagenic properties. It is incorporated into RNA and DNA, disrupting …

A first-generation demethylating agent is 5-azacytidine (5-Aza), an FDA-approved drug for the treatment of myelodysplastic syndromes . Once incorporated into DNA, 5-Aza irreversibly …

5-Azacytidine is a pyrimidine nucleoside analog that has been discovered more than 40 years ago. Despite remarkable responses in the treatment of acute myeloid leukemias in the 1970s …