3 天之前 · BMJ Supportive & Palliative Care holds an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. The Journal is …

Clinical trial staging. Single-arm trials are a commonly used clinical trial design that can be applied in all four phases of clinical trials. In the phase I clinical trials, single-arm trials are employed to investigate the mechanism of action, pharmacokinetic properties and safety of a new drug, providing foundational data for subsequent clinical trials.15 The phase II trials aim to evaluate ...

Results A total of 32 randomised controlled trials involving 1515 cancer survivors and 1845 patients with cancer undergoing treatment were included. The meta-analysis indicated a significant effect of cognitive–behavioural therapy on fear of cancer recurrence in patients with cancer and cancer survivors compared with controls (g=−0.65; 95% CI=−0.86, –0.44; p<0.001).

Background The anticipatory prescribing of injectable medications is recommended practice in controlling distressing symptoms in the last days of life. A 2017 systematic review found practice and guidance was based on inadequate evidence. Since then, there has been considerable additional research, warranting a new review. Aim To review the evidence published since 2017 concerning anticipatory ...

Introduction Caregivers play a major role in providing all the support and care in daily activities for their relatives with dementia. To fully describe the influence of dementia caregiving on family caregivers’ life, we conducted a systematic review including caregivers’ perceptions about the positive and negative aspects of caring and the expressed factors. Materials and methods We ...

2024年10月22日 · Objectives To investigate the efficacy and safety of oral (PO) and subcutaneous (SC) lacosamide for refractory symptoms in the palliative setting. Methods We conducted a retrospective chart review of the use of lacosamide since it was introduced in our palliative care service 1½ years ago. All clinical notes, medication administration records and infusion monitoring documentation were ...

Introduction. Most patients with a deteriorating chronic illness have a reduced oral intake at the end of life. This may be due to illness or treatment-related symptoms or complications, such as dysphagia, nausea or vomiting, generalised weakness and, in the last days of life, to a decreased level of consciousness or a loss of desire to drink.1 2 …

Clonidine is an alpha-2 adrenergic agonist licensed in the UK for hypertension, menopausal hot flushes and migraine prophylaxis. Randomised controlled trials (RCTs) confirm clonidine’s analgesic benefit in cancer pain (spinal), postoperative pain (intravenous (IV) spinal) and neuropathic pain (spinal and oral).1 2 IV clonidine achieves comparable analgesia to epidural clonidine, although ...

Introduction In 2021, we undertook a nation-wide online survey to explore public attitudes to death and dying in the UK (PADDUK).1 Due to the complexity and changing nature of public attitudes, we have been re-commissioned by Marie Curie to carry out an updated survey. Aim To explore current public attitudes to death, dying and bereavement in the UK and any changes in …

Contents Volume 14 Issue e1 | BMJ SP Care May 2024 e228 Advance care planning evaluation: a scoping review of best research practice S Gloeckler, T Krones, N Biller-Andorno e235 quality of lifeStatus, demand and practice models of palliative day-care clinics and day hospices: a scoping