Retinoic acid receptors were discovered during early studies of the actions and mechanisms of essential vitamins. Vitamin A is metabolized in the body to retinoic acid (RA) which is a key …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

The Retinoic Acid Receptors (RARs) and Retinoid X Receptors are among the most intensely studied nuclear hormone receptors. These proteins mediate both the organismal and cellular …

Retinoic acid, the main derivative of vitamin A, binds to nuclear receptors, retinoic acid receptor (RAR) and retinoic X receptor (RXR) to regulation gene transcription. RA plays an important …

At the molecular level, the action of RA is mediated by two distinct classes of proteins: (i) a family of nuclear receptors comprising RA receptors (RARs) and retinoid X receptors (RXRs) that …

The retinoic acid receptors and retinoid X receptors are each composed of three different subtypes, labeled α, β, and γ [9]. Nuclear retinoid receptors exist as dimers, and retinoic acid …

2022年11月1日 · The retinoic acid receptors (RARα, β, and γ) are multi-domain polypeptides that heterodimerize with retinoid X receptors (RXRα, β, and γ) to form functional transcription …

Retinoic acid receptors are members of the nuclear receptor (NRs) superfamily, which act as ligand-regulated trans-acting transcription factor binding to cis-acting DNA regulatory elements …

2018年1月1日 · The retinoic acid receptors (RARs) are ligand-dependent transcription factors that belong to the NR1B subtype of the nuclear receptor (NR) superfamily. RARs are ligand …

Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth, differentiation, survival …