HLA-DR refers to a subtype of HLA genes that encode for MHCII molecules, which are responsible for presenting peptides to CD4 receptors and promoting antibody production. It is …

HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail. Both α and β …

HLA-DR antigen specificities (i.e., DR1 to DR18) are determined by the polymorphic DRβ1 chains encoded by DRB1 alleles. HLA haplotypes of certain DRB1 alleles contain specifically linked …

The strongest determinant is HLA-DR, followed by HLA-B and HLA-A. These 3 loci are therefore the most important for matching donor and recipient. Some autoimmune disorders are linked …

HLA-DR is expressed by approximately one third of effector Tregs in adult human PB. HLA-DR + Tregs express higher levels of FoxP3 and are responsible for contact-dependent in vitro …

Our optimized procedure to isolate HLA-DR peptides from low cell numbers included cell lysis, immunoprecipitation of HLA-DR, elution of HLA-DR bound peptides, desalting and peptide …

HLA-DR. Major histocompatibility complex (MHC) II cell surface receptor (HLA-DR) is one of the key cell surface molecules expressed on antigen presenting cells (monocytes, macrophages, …

2023年5月4日 · The MHC-II proteins HLA-DR, HLA-DQ and HLA-DP are heterodimers consisting of a highly polymorphic β-chain and an α-chain showing little (HLA-DQ and HLA-DP) or almost …

HLA-DR level in cytotoxic T cells is a clinically validated predictive biomarker of breast cancer patients’ response to NACT. (A) Percentage of infiltrating cytotoxic T cells (CTLs) in NACT …

2023年12月20日 · The Hla Dr gene, also known as the human leukocyte antigen (HLA-DR) gene, is an important gene in the major histocompatibility complex (MHC) class II region. This gene …