RAS proteins in Drosophila melanogaster and Caenorhabditis elegans regulate pathways that are strikingly similar to the canonical RAS-MAPK pathway in mammalian cells (Lusk et al., 2017).

Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, these are important in controlling several functions, such as cell growth and survival.

Addgene's collection of plasmids for the Ras pathway. Ras is a small GTPase and constitutively active Ras is the most common oncogene in human cancer.

2023年12月18日 · RAS/RAF/MAPK can be activate via two pathways: (1) a ligand-dependent pathway, in which ligands, such as growth factors, hormones, or cytokines, physically engage with receptors; and (2) a...

2021年7月8日 · What is the Ras signaling pathway? H-Ras, K-Ras and N-Ras are closely related proteins that are frequently mutated in human cancers. Specifically, they are different isoforms of small, guanosine triphosphatases (GTPases) that function as …

The RAS proteins in turn signal through three alternative pathways to affect many downstream targets including TP53, RB1, and MTOR. Arrows represent activation signals, dotted "T" lines represent inhibitory signals.

This review will summarize the role of Ras pathway mutations in pediatric leukemia, discuss the current state of RAS pathway inhibitors and highlight the most promising agents currently being evaluated in clinical trials.

The RAS proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation.