Ubiquitin is a small protein that exists in all eukaryotic cells. It performs its myriad functions through conjugation to a large range of target proteins. A variety of different modifications can occur. The ubiquitin protein itself consists of 76 amino acids and has a …

2021年1月14日 · Today, we know that ubiquitin regulates virtually all aspects of eukaryotic biology. All eukaryotes—from yeast to humans—express the enzymatic machinery to covalently modify substrate proteins...

2004年11月29日 · Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein.

By precisely regulating protein quality and quantity, ubiquitination is essential for maintaining protein homeostasis, DNA repair, cell cycle regulation, and immune responses.

2023年3月16日 · Ubiquitination is a three-step process involving three enzymes: ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin-protein ligase (E3). E1 activates ubiquitin in an ATP-dependent manner, enabling …

2018年8月23日 · Ubiquitin is a small protein that is found in almost all cellular tissues in humans and other eukaryotic organisms, which helps to regulate the processes of other proteins in the body. Through a...

2024年2月28日 · Ubiquitin is a small (8.6 kDa) protein that is found ‘ubiquitously’ in eukaryotic organisms and functions as a regulator of numerous cellular processes. It is a multifaceted post-translational modifier of other proteins involved in almost all eukaryotic biology.

2018年8月23日 · The most widely regarded function of ubiquitin is its ability to mark proteins that need to be degraded by the proteasome. It is for this reason that it is occasionally referred to...

Understanding the structure and functions of ubiquitin is essential for comprehending how it modulates protein activities, influences cellular regulation, and determines the fate of proteins in the cell.

Ubiquitin function. Ubiquitin through its chemical conjugation onto proteins (ubiquitination) plays major roles in regulating almost all cellular processes from tagging them for proteasomal degradation (protein degradation), protein trafficking, cell-cycle regulation, DNA repair, apoptosis and signal transduction 2 and protein-protein ...