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  1. Nature
    https://www.nature.com › articles

    Genome-wide quantification of ADAR adenosine-to-inosine RNA …

    • For any set of predetermined genomic regions, the editing index is defined (Fig. 1a,b) as the ratio of the number of A-to-G mismatches (mismatches between RNA-seq reads aligned to the regions of interest and t… 展开

    Robustness of The Editing Index

    The purpose of the AEI is to allow a quantitative comparison of various RNA-seq samples, … 展开

    Nature
    Comparison with Alternative Approaches

    RNA edits can be systematically and directly observed in RNA-sequencing data, as inosines appear in the sequencing data as guanosines. Various algorithmic approaches and … 展开

    Nature
    Alu Editing in Various Tissues and Conditions

    We now turn to demonstrate how the AEI can be used to chart the editome across various conditions and tissues. First, we calculate the AEI for 8,848 GTEx samples, of 47 different tis… 展开

    Nature
    QEdit: RNA editing quantification in deep transcriptome data
    The Alu editing index (AEI) is a metric to quantify the global RNA editing activity of sample and is defined as the weighted average of editing events occurring in all Alu elements. The pipel…
    Github · https://github.com/BioinfoUNIBA/QEdit
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    目录
    Robustness of The Editing Index
    Comparison with Alternative Approaches
    Alu Editing in Various Tissues and Conditions
     
  1. Github
    https://github.com › RNAEditingIndexer

    a2iEditing/RNAEditingIndexer - GitHub

  2. rnabioco.github.io
    https://rnabioco.github.io › raer › reference › calc_scAEI.html

    Calculate the Adenosine Editing Index (AEI) in single cells

  3. Nature
    https://www.nature.com › articles

    Divergent landscapes of A-to-I editing in postmortem and

  4. Github
    https://github.com › BioinfoUNIBA › QEdit

    QEdit: RNA editing quantification in deep …

    The Alu editing index (AEI) is a metric to quantify the global RNA editing activity of sample and is defined as the weighted average of editing events occurring in all Alu elements. The pipeline to calculate AEI is described in Roth et al. …

  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Genome-wide quantification of ADAR adenosine-to-inosine RNA …

  6. 其他用户还问了以下问题
    What is the AEI and how does it work?
    The AEI was developed by Roth and co-workers and is a power computational tool that maps editing in Alu repeats across large data sets generated from RNA sequencing and has become widely accepted as the gold standard for quantifying ADAR editing activity.

    Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V

    pubs.acs.org
    What is the ALU editing Index (AEI)?
    Methods for quantification of ADAR activity are sought after, due to an increasing interest in the role of ADARs in cancer and autoimmune disorders, as well as attempts to harness the ADAR enzymes for RNA engineering. Here, we present the Alu editing index (AEI), a robust and simple-to-use computational tool devised for this purpose.

    Genome-wide quantification of ADAR adenosine-to-inosine RNA editing

    nature.com
    What is a-to-I editing?
    The most widespread technique used to characterize A-to-I editing is RNA sequencing (RNA-seq), in which RNA is extracted from cells, pooled, and subjected to high-throughput sequencing. Resulting sequences are compared to a reference genome, and edited sites are identified from A–G transitions.

    Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V

    pubs.acs.org
    How is AEI quantified?
    The AEI is quantified by measuring the total number of edited adenosines over all adenosines with supporting RNA-sequencing read coverage in Alu elements across the entire transcriptome and is a metric of global Alu editing activity (see Materials and Methods) (Supplementary Data 1).

    Divergent landscapes of A-to-I editing in postmortem and ... - Nature

    nature.com
    What does AEI stand for?
    A Alu editing index (AEI; y axis) computed on bulk RNA-seq from living and postmortem (PM) DLPFC. Two-sided linear regression was used to test for significance. B ADAR, ADARB1, and ADARB2 normalized expression profiles on bulk including RNA-seq between living and PM.

    Divergent landscapes of A-to-I editing in postmortem and ... - Nature

    nature.com
    How does a-to-I editing affect cellular pathways?
    A-to-I editing is the most widespread post-transcriptional modification and is essential for multiple biological processes. One way that editing impacts cellular pathways is thought to be through directing the localization of RNAs to subcellular compartments by editing within the 3′ UTR of mRNAs.

    Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V

    pubs.acs.org
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  7. 科学网
    https://news.sciencenet.cn › htmlpaper

    新工具可定量分析RNA碱基编辑器活性 - 科学网

  8. ACS Publications
    https://pubs.acs.org › doi

    Spatial Visualization of A-to-I Editing in Cells Using …

    2024年7月7日 · A-to-I editing is the most widespread post-transcriptional modification and is essential for multiple biological processes. One way that editing impacts cellular pathways is thought to be through directing the …

  9. rnabioco.github.io
    https://rnabioco.github.io › raer › reference › calc_AEI.html

    Calculate the Adenosine Editing Index (AEI) — calc_AEI

  10. Frontiers
    https://www.frontiersin.org › journals › genet…

    Quantifying RNA Editing in Deep Transcriptome Datasets

    2020年3月5日 · Identification of differential RNA editing is most relevant at recoding sites, where altered A-to-I levels could lead to different protein isoforms. Editing dysregulation at recoding sites between two groups of samples is often …