2023年7月18日 · This narrative review explores the physiology and evidence-based management of patients with severe acute respiratory distress syndrome (ARDS) and refractory hypoxemia, with a focus on mechanical ventilation, adjunctive therapies, and veno-venous extracorporeal membrane oxygenation (V-V ECMO). Severe ARDS cases increased dramatically worldwide …

2024年8月26日 · The optimal strategy for positive end-expiratory pressure (PEEP) titration in the management of severe acute respiratory distress syndrome (ARDS) patients remains unclear. Current guidelines emphasize the importance of a careful risk–benefit assessment for PEEP titration in terms of cardiopulmonary function in these patients. Over the last few decades, the …

2024年2月23日 · Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disability for months to years after hospitalization. These findings underscore the importance of extended follow-up to assess and address the Post …

2024年1月12日 · Improving management of ARDS: uniting acute management and long-term recovery Nicola Latronico1,2,3*, M. Eikermann4,5, E. W. Ely6,7 and D. M. Needham8,9,10,11 Abstract Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality.

2021年2月25日 · Background Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients. Methods This was a post hoc analysis of …

2020年3月24日 · The acute respiratory distress syndrome (ARDS) is a clinical syndrome defined by acute onset hypoxemia (PaO 2:FiO 2 ratio < 300) and bilateral pulmonary opacities not fully explained by cardiac failure or volume overload . The Berlin consensus definition of ARDS, like the American-European Consensus definition that preceded it, has enabled ...

2024年5月27日 · Although MV is considered one of the cornerstones of ARDS management, the recognition that it can contribute to LI represents a significant advancement in ARDS research [23, 24, 47]. Termed ventilator-induced lung injury (VILI), this phenomenon involves a range of mechanisms, including exposure to elevated inflation transpulmonary pressures ...

2024年10月24日 · Background Sub-phenotyping of acute respiratory distress syndrome (ARDS) could be useful for evaluating the severity of ARDS or predicting its responsiveness to given therapeutic strategies, but no studies have yet investigated the heterogeneity of patients with severe ARDS requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO). …

2023年10月31日 · Although the defining elements of “acute respiratory distress syndrome” (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its conceptual definition, it remains a matter of debate whether ARDS is a discrete nosological entity. After almost 60 years, it is appropriate to examine how …

2021年11月23日 · Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the …