The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, …

By definition, all β-lactam antibiotics have a β-lactam ring in their structure. The effectiveness of these antibiotics relies on their ability to reach the PBP intact and their ability to bind to the PBP.

2023年6月4日 · The beta-lactam ring stands alone and not fused to another ring. Beta-lactamase inhibitors. They work primarily by inactivating serine beta-lactamases, which are enzymes that …

The structural characteristics of a β-lactam ring provide higher reactivity for β-lactam antibiotics to inactivate penicillin-binding proteins (PBPs) than a linear, five- or six-membered ring and …

Resistance to β-lactams is primarily because of bacterially produced β-lactamase enzymes that hydrolyze the β-lactam ring, thereby inactivating the drug. The newest effort to circumvent …

The β-lactams are the most widely used class of antibiotic. 1,2 The antibiotics in this group are characterized by a reactive four-membered β-lactam ring, which is essential to their …

2012年2月3日 · The β-lactam ring is considered the central motif of the main drugs utilized for the treatment of several bacterial infections such as ampicillin and amoxicillin [14]. The …

Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on …

2024年11月23日 · The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which …

2013年3月27日 · Isopenicillin N synthase is responsible for formation of the β-lactam ring in all penicillin/cephalosporin compounds, and the reaction catalyzed is completely separate from …