The role of BRCA1 in DNA damage response - PMC - PubMed …
The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis.
The role of BRCA1 in DNA damage response - PubMed
The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis.
BRCA1 levels and DNA-damage response are controlled by the …
2024年10月9日 · CircHIPK3 depletion or disruption of the circRNA-mRNA interaction decreases BRCA1 protein levels and increases DNA damage, sensitizing several cancer cells to DNA-damage-inducing agents and rendering them susceptible to synthetic lethality.
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and
2020年2月24日 · The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from...
BRCA1 in the DNA damage response and at telomeres - PMC
Here, we will review BRCA1 functions in the DNA damage response (DDR), which are likely to contribute to tumor suppression. In the process, we will highlight some of the controversies and unresolved issues in the field.
BRCA1 and BRCA2: different roles in a common pathway of …
However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair. BRCA1 is a pleiotropic DDR protein that functions in both checkpoint activation and DNA repair, whereas BRCA2 is a mediator of the core mechanism of homologous recombination.
Function of BRCA1 in the DNA damage response is mediated by …
2013年5月5日 · BARD1 mediates the rapid recruitment of BRCA1 to DNA damage sites. To search for the molecular mechanism by which BRCA1 is recruited to DNA damage sites, we measured the kinetics of BRCA1’s relocation to sites of DNA damage.
Systematic investigation of BRCA1-A, -B, and -C complexes and
2024年7月27日 · BRCA1, a breast cancer susceptibility gene, has emerged as a central mediator that brings together multiple signaling complexes in response to DNA damage.
Function of BRCA1 in the DNA Damage Response Is Mediated …
2013年5月13日 · Accumulated evidence shows that BRCA1 is quickly recruited to DNA lesions and plays an important role in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive. BRCA1 forms a Ring-domain heterodimer with BARD1, a major partner of BRCA1 that contains tandem BRCA1 C-terminus …
Function of BRCA1 in the DNA damage response is mediated by …
2013年5月13日 · Accumulated evidence shows that BRCA1 is quickly recruited to DNA lesions and plays an important role in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive.
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